A selection of about 500 formulations of human and veterinary drugs are presented in this booklet. They have all been developed in the last 20 years in the Applications Laboratories of BASF AG and are in solid, liquid, and semi-solid form. However, emphasis is placed on tablets. Human and veterinary medicines have not been dealt with in separate chapters, because the technologies and excipients are the same
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Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis , 2nd Edition
Robert A. Copeland
ISBN: 0-471-35929-7
Hardcover
416 pages
April 2000
Wiley List Price: US $125.00
Fully updated and expanded-a solid foundation for understanding experimental enzymology.
This practical, up-to-date survey is designed for a broad spectrum of biological and chemical scientists who are beginning to delve into modern enzymology. Enzymes, Second Edition explains the structural complexities of proteins and enzymes and the mechanisms by which enzymes perform their catalytic functions. The book provides illustrative examples from the contemporary literature to guide the reader through concepts and data analysis procedures. Clear, well-written descriptions simplify the complex mathematical treatment of enzyme kinetic data, and numerous citations at the end of each chapter enable the reader to access the primary literature and more in-depth treatments of specific topics.
This Second Edition of Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis features refined and expanded coverage of many concepts, while retaining the introductory nature of the book. Important new features include:
A new chapter on protein-ligand binding equilibria
Expanded coverage of chemical mechanisms in enzyme catalysis and experimental measurements of enzyme activity
Updated and refined discussions of enzyme inhibitors and multiple substrate reactions
Coverage of current practical applications to the study of enzymology
Supplemented with appendices providing contact information for suppliers of reagents and equipment for enzyme studies, as well as a survey of useful Internet sites and computer software for enzymatic data analysis, Enzymes, Second Edition is the ultimate practical guide for scientists and students in biochemical, pharmaceutical, biotechnical, medicinal, and agricultural/food-related research.
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Enzymes and Their Inhibitors: Drug Development - Enzyme Inhibitors
By H. John Smith and Claire Simons (Editors)
* Publisher: CRC
* Number Of Pages: 328
* Publication Date: 2004-07-15
* Sales Rank: 1182130
* ISBN / ASIN: 0415334020
Book Description:
Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibition provides an overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, substrates, kinetics, and mechanisms of enzymes. Subsequent chapters discuss various types of enzyme inhibitors and the principles involved in developing them into effective drugs. This book describes the problems that can be encountered in translating results from the bench to the market place, and suggests approaches that circumvent these difficulties. This outstanding text for students in pharmacology and medicinal chemistry is also a valuable professional reference.
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Evaluation Of Enzyme Inhibitors In Drug Discovery
Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists
(Methods of Biochemical Analysis)
By Robert A. Copeland
* Publisher: Wiley-Interscience
* Number Of Pages: 296
* Publication Date: 2005-03-28
* Sales Rank: 402011
* ISBN / ASIN: 0471686964
* EAN: 9780471686965
Book Info:
This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications.
Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address:
* What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism?
* How are inhibitors evaluated for potency, selectivity, and mode of action?
* What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo?
* What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization?
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