Book For Protein Structure Prediction (Methods in Molecular Biology)

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»Book Publisher: Humana Press (12 September, 2007)
»ISBN: 1588297527
»Book author: Mohammed Zaki, Chris Bystroff
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Book Description:

This book covers elements of both the data-driven comparative modeling approach to structure prediction and also recent attempts to simulate folding using explicit or simplified models. Despite the unsolved mystery of how a protein folds, advances are being made in predicting the interactions of proteins with other molecules, such as small ligands, nucleic acids or other proteins. Also rapidly advancing are the methods for solving the inverse folding problem, the problem of finding a sequence to fit a structure. This book focuses on the various computational methods for prediction, their successes and their limitations, from the perspective of their most well known practitioners.

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Length:3.3 MB
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Book-Neuroprotection Methods and Protocols (Methods in Molecular Biology)

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»Book Publisher: Humana Press (08 August, 2007)
»ISBN: 1588296660
»Book author: Tiziana Borsello
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Book Description:

This book examines current research and methods into neuronal death signaling pathways, with the main aim of providing an overview of methods used to study neuronal death and neuroprotection and offering a truly comprehensive, step-by-step guide that makes clear not just the procedure but also the principles behind the use of it.

Length:2.2 MB
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Book For Microbial Gene Essentiality: Protocols and Bioinformatics (Methods in Molecular Biology)

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»Book Publisher: Humana Press (04 February, 2008)
»ISBN: 1588293785
»Book author: Andrei L. Osterman, Svetlana Gerdes
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Book Description:

Microbial Gene Essentiality: Protocols and Bioinformatics contains a comprehensive collection of experimental and computational strategies and techniques for microbial genome-scale essentiality studies, developed and presented by the leading groups in the field. In addition to wet-lab protocols, the book describes (i) statistical methods essential for planning successful large-scale essentiality screens, as well for data evaluation and analysis; (ii) in-silico prediction of gene essentiality using genome-scale reconstructed metabolic models; and (iii) data integration and comparative analysis in the context of genomic databases. This volume provides researchers with a first-stop guide for choosing the most appropriate strategy for planned essentiality studies. Experimental and computational aspects are equally important in genome-scale gene essentiality analysis, as in all other genomic technologies, and Microbial Gene Essentiality: Protocols and Bioinformatics reflects both of these aspects. All protocols follow the successful Methods in Molecular Biology series format, each offering an introduction outlining the principles behind the techniques, step-by-step instructions, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls, and are intended for both novice and expert scientists.

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Length:6.9 MB
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